Exploring the possibilities of using in vitro model for neuropathic pain studies

Establishing experimental models to study neuropathic pain has been challenging due the complex mechanism underlying condition. Although in vivo have useful observation of behavioural responses, it should be acknowledged that species-to-species variance can lead differences terms molecular and genetic expression. The signal transduction using faces limitations ethical considerations involving induction animals intricacy interactions pathophysiology Hence, developing relevant vitro is important, as considers physiological microenvironment reduces use animals. Several taken into account an model pain, including either primary culture cell lines with their origins; human or animal, method pain-like assays assess pain. This review recapitulates previous research employing investigating intending provide alternative growing concerns on models.